You may be tempted to fake a close-up shot by taking a regular image and cropping it. In some situations, that will work. But while you'll get a large subject with that effort, you'll lose some detail. Look at these images, right. Tracy Kyle shot the tiny skateboards both with and without the macro setting on her camera. She was able to get fairly close without the macro setting, but with it she was able to move in even tighter, capturing more details. Tracy will be able to print the macro image quite large without losing quality.
Often having a recognizable item in the shot with your tiny object gives it a sense of scale, such as the fingers in this photo. This becomes especially helpful when capturing items that have large look-a-likes, such as tiny love notes, mini doll furniture, or holiday ornaments.